癌变·畸变·突变 ›› 2004, Vol. 16 ›› Issue (2): 86-88.doi: 10.3969/j.issn.1004-616x.2004.02.006

• 论著 • 上一篇    下一篇

食管癌及其癌前病变患者血清补体总活性与红细胞CR1表达及临床意义分析

任金荣;孙丽霞;杨淑琴;何兰欣;艾　军   

  1. 河北医大第四医院肿瘤研究所免疫室,河北　石家庄　050011
  • 收稿日期:2003-11-13 修回日期:2004-01-06 出版日期:2004-03-30 发布日期:2004-03-30
  • 通讯作者: 任金荣

Clinical Significance of Complement Activities in the Serum and Erythrocyte CR1 Adherence Function in Patients with Esophageal Carcinoma and Precancerous Lesions

REN Jin-rong, SUN Li-xia, YANG Shu-qin, et al   

  1. Insititute of Immunology,The Fourth Hospital,Hebei Medical University,Shijiazhuang,050011,China
  • Received:2003-11-13 Revised:2004-01-06 Online:2004-03-30 Published:2004-03-30
  • Contact: REN Jin-rong

摘要： 背景与目的: 探讨食管癌及其癌前病变机体免疫功能变化及其临床意义。材料与方法: 分别采用微量快速平板补体活性测定法和补体致敏酵母菌花环实验对60例食管癌、75例食管上皮细胞重度不典型增生I、II级患者的血清总补体活性及红细胞黏附功能进行测定。结果: 食管癌患者血清总补体活性平均为39.8(13.7～115.3)，食管上皮细胞重度不典型增生I、II级患者组分别为29.35(11.1～78.5)和41.5(12.2～138.1)，均明显高于正常对照组16.2(7.7～34.1)(P<0.01)；食管癌患者组红细胞CR1黏附活性为(18.9±5.8)％，食管上皮细胞重度不典型增生I、II级患者组分别为(23.6±3.8)％和(21.3±4.5)％，与正常对照组(27.2±6.9)％相比均有明显降低(P<0.01)。结论: 患者血清总补体活性及红细胞CR1黏附活性均发生了明显变化，且与病变程度有关。可应用于食管癌早期辅助诊断及病程变化监测。

关键词: 食管癌, 癌前病变, 补体, 红细胞免疫

Abstract: BACKGROUND ＆ AIM:To study clinical significance of immune function variation in the patients with esophageal carcinoma and precancerous lesions.MATERIAL AND METHODS: The complement activities and erythrocyte CR1 adherence function were measured in 60 esophageal patients and 75 precancerous lesions by using trace fast plate complement activity assay and complement activating yeast rosette test,respectively.RESULTS:The average activities of complement were 39.8(13.7～115.3),29.5(11.1～78.5) and 41.5(12.2～138.1) 0respectively in esophageal cancer group and in the groups of atypical hyperplasia I and II phase. The activities of these groups were much higher than that of the health control group. 16.2(7.7～34.1)(P<0.01).Erythrocyte CR1 adherence activity of esophageal carcinoma group was (18.9±5.8)％ and other two precancerous lesions groups were (23.6±3.8)％ and (21.3±4.5)％. These activities were much lower than that of the health control group.(27.2±6.9)％(P<0.001). CONCLUSION: There are different variances in the complement activity and erythrocyte immune adherencefunction have changed significantly in the patients with esophageal carcinoma and precancerous lesions and relative to the lesion phase.It may be to help to diagnose or monitor lesion in early stage.

Key words: esophageal, precancerous lesion, complement, erythrocyte immune

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